KLOE-2 is the main experiment of the Frascati National Laboratories and represents the continuation of the KLOE experiment, upgraded with new detectors, concentrates of state of the art technology to improve its discovery potential. KLOE completed its data acquisition in 2006 and has made a fundamental contribution to the understanding of various questions of modern physics, including the most accurate measurement to date of one of the elements of the quark mixing matrix, for which the Japanese physicists Kobayashi and Maskawa were awarded the Nobel prize in 2008. One of the main objectives of KLOE-2 is the study of spectacular quantum interference phenomena of neutral K-mesons produced at DAFNE together with the very high precision study of the intrinsic properties of particles of matter (kaons) compared to those of anti-matter (anti kaons); the possible observation of even a minimal difference between the two would imply the need to revise the fundamental laws of physics, providing the first experimental indication of a quantum theory of gravity that reconciles Einstein’s general relativity theory with Quantum Mechanics. In November 2014 began the first data acquisition phase of KLOE-2, Run-I, which was successfully completed in July, with the observation of about 1 billion neutral K-mesons. Currently Run-II is in progress aiming to collect more than 5 billion neutral K-mesons in the next 2-3 years.