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Tag Archives: Evento scientifico

The morphological analysis of the collagen straightness in the colon mucosa away from the cancer

The morphological method – based on the topology and singularity theory and originally developed for the analysis of the scattering experiments – was extended to be applicable for the analysis of biological data. The usefulness of the topological viewpoint was demonstrated by quantification of the changes of collagen fiber straightness in the human colon mucosa (healthy mucosa, colorectal cancer, and uninvolved mucosa far from cancer). This has been done by modeling the distribution of collagen segment angles by the polymorphic beta-distribution. Its shapes were classified according to the number and type of critical points. We found that biologically relevant shapes could be classified as shapes without any preferable orientation (i.e. shapes without local extrema), transitional forms (i.e. forms with one broad local maximum), and highly oriented forms (i.e. forms with two minima at both ends and one very narrow maximum between them). Thus, changes in the fiber organization were linked to the metamorphoses of the beta-distribution forms. The obtained classification was used to define a new, shape-aware/based, measure of the collagen straightness, which revealed a slight, and moderate increase of the straightness in mucosa samples taken 20 cm and 10 cm away from the tumor. The largest increase of collagen straightness was found in samples of cancer tissue. Samples of the healthy individuals have a uniform distribution of beta-distribution forms. We found that this distribution has the maximal information entropy. At 20 cm and 10 cm away from cancer, the transition forms redistribute into unoriented and highly oriented forms. Closer …

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Quantifying organization of collagen fibers in the uninvolved human colon mucosa 10 cm and 20 cm away from the malignant tumor

Changes in morphology and organization of collagen fibers contribute to the formation of a microenvironment which facilitate tumor progression through the impact on migration and polarization of the cells [1]. Changes in morphology and organization of collagen fibers in cancer, itself, are the subject of numerous studies, while it is far less known about the changes in collagen fibers in the uninvolved mucosa away from cancer The main histochemical staining for detection of collagen fibers under light micrsocpy is Masson trichrome staining. Recently, second harmonic generation (SHG) imaging of collagen fibers using nonlinear laser scanning micrscopy emerged as a poweful tool enabeling imaging of collagen fibers in unstained and unfixed tissue [2]. Due to growing interest in role of collagen fibers in cancer progression, the number of methods for quantification of different parameters of collagen fibers is increasing. Currently available methods are based on the intensity derivates, intensity variation, Fourier transform, Hough transform, directional filters and fiber tracking algorithm [3]. The aim of our study was to analyse changes in morphology and organization of collagen fibers in the uninvolved colonic mucosa 10 cm and 20 cm away from the cancer, in comparison with healthy subjects, using Masson trichrome staining, SHG imaging and multiple complementary methods for quantification.

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Far forward detectors at the high luminosity LHC

The Forward Physics Facility (FPF) is a cavern with the space and infrastructure to support a suite of far-forward experiments at the Large Hadron Collider during the High Luminosity era. Located along the beam collision axis and shielded from the interaction point by at least 100 m of concrete and rock, the FPF will house experiments that will detect particles outside the acceptance of the existing large LHC experiments and will observe rare and exotic processes in a low-background environment. We will talk about the current status of plans for the FPF, including recent progress in civil engineering in identifying promising sites for the FPF and the experiments currently envisioned. We briefly review the physics topics that will be advanced by the FPF, including searches for long-lived particles, probes of dark matter and dark sectors, high-statistics studies of TeV neutrinos of all three flavors, aspects of perturbative and non-perturbative QCD, and high-energy astroparticle physics. And then discuss the nature of detectors that are needed for this adventure including a liquid argon TPC which will push the state of the art for such detectors.     Join Zoom Meeting https://infn-it.zoom.us/j/87005285608?pwd=MFRTNkZtelIvVXpQeTVuTlBFekxCUT09 Meeting ID: 870 0528 5608 Passcode: 735455      

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Bulk MicroMegas chambers construction

Bulk Micromegas detectors are well known for their good spatial and time resolution, and simplicity of manufacturing and maintenance which are widely applied in various experiments. In this presentation there are described two main JINR (Joint Institute for Nuclear Research) technological contributions based on HL-LHC upgrade projects: NSW upgrade project and Compass++/AMBER program at CERN. Within the upgrade projects here are presented the main technological chain and performance of MicroMegas chamber.     Join Zoom Meeting https://infn-it.zoom.us/j/85899837821?pwd=NFQ2eHBIbllvV1JYYlFOVGFqUk5XUT09 Meeting ID: 858 9983 7821 Passcode: 768668      

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65th ICFA Advanced Beam Dynamics Workshop on High Luminosity Circular e+e- Colliders (eeFACT2022)

NEW:   DEADLINE EXTENDED TO AUGUST 5TH The workshop will be held – in person – at the INFN-LNF, Via Enrico Fermi, 54 – Frascati (Rome, Italy) from September 12 to 15, 2022. The INFN Frascati National Laboratories is hosting the ICFA Advanced Beam Dynamics Workshop on High Luminosity Circular e+e- Colliders (eeFACT2022). This workshop is organized in the context and with sponsoring of the ICFA Beam Dynamics Panel and EU/IFAST funded European Network for Accelerator Performance and Concepts (APEC). eeFACT2022 scope: Reviewing and documenting the state of the art in e+e- factory design Reviewing and drawing lessons from SuperKEKB phase 3 commissioning Catalyzing further contributions to the SuperKEKB, FCC, CEPC & tau-charm design efforts Fostering synergies and new collaborations across communities, in particular with low-emittance light sources and other colliders (muon, linear, e-ion) and between continents Jointly developing novel solutions to outstanding problems Participants in the Workshop are invited to register via web using the online registration form. The registration fee of 300,00 Euros, as contribution to the Workshop organisation, includes lunches, coffee breaks, a welcome cocktail, a social dinner and meeting materials. Attendance on site is highly encouraged and we will be pleased to welcome you again in Frascati! Please note that NO green pass is required in order to enter Italy at the moment. REGISTRATION AND FEE PAYMENT DEADLINE: 5 AUGUST 2022 Workshop Organizing Committee: M.E. Biagini (INFN-LNF, Italy) (LOC chair) A. Blondel (CERN, Switzerland) Y. Funakoshi (KEK, Japan) Y. Li (IHEP, China) Q. Qin (ESRF, France) F. …

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Brave New Worlds: The Discovery and Characterisation of Planets Beyond Our Solar System

Over the past three decades astronomers have discovered over 5000 planets orbiting distant stars – known as “exoplanets”. In this talk I will outline the ingenious methods that have been used to overcome the extreme challenges involved in finding these exoplanets. I will discuss the stunning variety of exoplanets that we have found, and what we have learnt from these discoveries. I will then discuss how we are able to learn more about these planets using observations that probe their orbits, temperatures, and even compositions. Finally I will finish by looking ahead to what the future might hold in terms of uncovering planets and even life beyond our Solar System.

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XX FRASCATI SUMMER SCHOOL “BRUNO TOUSCHEK” in Nuclear, Subnuclear and Astroparticle Physics

The XX LNF Summer School “Bruno Touschek” in Nuclear, Subnuclear and Astroparticle Physics will take place at the INFN, Laboratori Nazionali di Frascati, Italy from Monday, July 11th to Friday, July 15th, 2022. The School is intended for graduate students and post-doctoral fellows in theoretical and experimental high-energy physics. The 2022 edition of the School includes lectures on selected theoretical and experimental topics, discussion sessions, and the 7th Young Researchers Workshop on `Physics Challenges in the LHC Era’, which will take place on Monday, July 11th and on Thursday, July 14th. Students planning to participate in the School are strongly encouraged to apply to give a presentation of their research in the workshop, by sending an email to gennaro.corcella@lnf.infn.it, with a copy to school@lnf.infn.it, with the proposed talk title. The contributions will be published in Frascati Physics Series. A few fellowships covering the registration fee and/or accommodation are available for selected participants giving talks. The 2022 edition of the School consists of six sets of lectures, divided equally between theoretical and experimental topics, two discussion sessions, and a colloquium for a general audience on `Brave New Worlds: Discovery and Characterisation of Planets Beyond our Solar System’. The deadline to apply to the school and possibly give a presentation in the workshop is June 15th. Lecture topics: Flavour physics in quark and charged-lepton sectors QCD and jets at colliders Projects for future accelerators Early Universe Cosmology Big Bang Nucleosynthesis Cosmic Microwave Background Invited Lecturers: Daniel Bayliss (Warwick U.) Matteo Cacciari (LPTHE …

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