A whole set of B-decay data display persistent deviations with respect to the Standard Model (SM). Specifically, data hint at new effects in semi-leptonic interactions involving the b -> s and b -> c currents. Interestingly, the pattern of discrepancies after the recent Run-2 updates suggest well-defined effective-field theory (EFT) scenarios where the two sets of discrepancies, b -> s and b -> c, are related. In turn, such EFT picture finds a quantitative realization within well-defined UV-complete scenarios. I will provide a review of the whole subject, from data to the EFT picture to UV models.