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X-ORIGINAL-URL:https://w3.lnf.infn.it
X-WR-CALDESC:Eventi per INFN-LNF
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TZID:Europe/Rome
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DTSTART:20220327T010000
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DTSTART:20221030T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Rome:20221003T090000
DTEND;TZID=Europe/Rome:20221010T140000
DTSTAMP:20260819T190019
CREATED:20220824T092242Z
LAST-MODIFIED:20221007T100325Z
UID:33353-1664787600-1665410400@w3.lnf.infn.it
SUMMARY:Visita AISF@SPARC_Lab
DESCRIPTION:Visita guidata ai Laboratori Nazionali di Frascati – SPARC LAB \nCon l’Associazione Italiana degli Studenti di Fisica è prevista una giornata di presentazioni delle attività sperimentali e visite al gruppo di laboratori di SPARC_Lab dei Laboratori Nazionali di Frascati.  \nI destinatari di questo evento sono tutti gli studenti di fisica dei corsi triennale\, magistrale e dottorato\, regolarmente iscritti ad AISF\, ai Comitati Locali di Sapienza Università di Roma e Università degli Studi di Roma Tre. \nGli studenti avranno modo di accedere all’acceleratore al plasma SPARC\, all’area di interesse del Laser di Alta Potenza FLAME ed al  Plasma_Lab. \nInoltre\, sarà possibile partecipare alle presentazione delle attività sperimentali e descrizione delle macchine acceleratrici in questione. \n  \nINFORMAZIONI GENERALI \nI Laboratori Nazionali di Frascati sono facilmente raggiungibili con il servizio ferroviario nazionale Trenitalia. Essi distano solo 3 minuti a piedi dalla stazione Tor Vergata.  \nSi ricorda che\, stando all’ultima normativa vigente per accedere ai trasporti pubblici è necessario indossare mascherina FFP2. \nPer ulteriori informazioni vi consigliamo di consultare il seguente sito web COME RAGGIUNGERCI o di contattarci
URL:/event/visita-aisfsparc_lab/
LOCATION:INFN – Laboratori Nazionali di Frascati\, Via Enrico Fermi\, 60\, Frascati\, 00044\, Italia
CATEGORIES:Outreach
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Rome:20221006T100000
DTEND;TZID=Europe/Rome:20221006T110000
DTSTAMP:20260819T190019
CREATED:20221006T084931Z
LAST-MODIFIED:20221007T100316Z
UID:33471-1665050400-1665054000@w3.lnf.infn.it
SUMMARY:Quantifying organization of collagen fibers in the uninvolved human colon mucosa 10 cm and 20 cm away from the malignant tumor
DESCRIPTION:Changes in morphology and organization of collagen fibers contribute to the formation of a microenvironment which facilitate tumor progression through the impact on migration and polarization of the cells [1]. Changes in morphology and organization of collagen fibers in cancer\, itself\, are the subject of numerous studies\, while it is far less known about the changes in collagen fibers in the uninvolved mucosa away from cancer The main histochemical staining for detection of collagen fibers under light micrsocpy is Masson trichrome staining. Recently\, second harmonic generation (SHG) imaging of collagen fibers using nonlinear laser scanning micrscopy emerged as a poweful tool enabeling imaging of collagen fibers in unstained and unfixed tissue [2]. Due to growing interest in role of collagen fibers in cancer progression\, the number of methods for quantification of different parameters of collagen fibers is increasing. Currently available methods are based on the intensity derivates\, intensity variation\, Fourier transform\, Hough transform\, directional filters and fiber tracking algorithm [3]. The aim of our study was to analyse changes in morphology and organization of collagen fibers in the uninvolved colonic mucosa 10 cm and 20 cm away from the cancer\, in comparison with healthy subjects\, using Masson trichrome staining\, SHG imaging and multiple complementary methods for quantification.
URL:/event/quantifying-organization-of-collagen-fibers-in-the-uninvolved-human-colon-mucosa-10-cm-and-20-cm-away-from-the-malignant-tumor/
LOCATION:Aula Seminari\, Via Enrico Fermi\, 40\, Frascati\, Roma\, 00044\, Italia
CATEGORIES:Seminari teorici
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Rome:20221006T110000
DTEND;TZID=Europe/Rome:20221006T120000
DTSTAMP:20260819T190019
CREATED:20221006T084931Z
LAST-MODIFIED:20221007T100316Z
UID:33473-1665054000-1665057600@w3.lnf.infn.it
SUMMARY:The morphological analysis of the collagen straightness in the colon mucosa away from the cancer
DESCRIPTION:The morphological method – based on the topology and singularity theory and originally developed for the analysis of the scattering experiments – was extended to be applicable for the analysis of biological data. The usefulness of the topological viewpoint was demonstrated by quantification of the changes of collagen fiber straightness in the human colon mucosa (healthy mucosa\, colorectal cancer\, and uninvolved mucosa far from cancer).\nThis has been done by modeling the distribution of collagen segment angles by the polymorphic beta-distribution. Its shapes were classified according to the number and type of critical points. We found that biologically relevant shapes could be classified as shapes without any preferable orientation (i.e. shapes without local extrema)\, transitional forms (i.e. forms with one broad local maximum)\, and highly oriented forms (i.e. forms with two minima at both ends and one very narrow maximum between them). Thus\, changes in the fiber organization were linked to the metamorphoses of the beta-distribution forms.\nThe obtained classification was used to define a new\, shape-aware/based\, measure of the collagen straightness\, which revealed a slight\, and moderate increase of the straightness in mucosa samples taken 20 cm and 10 cm away from the tumor. The largest increase of collagen straightness was found in samples of cancer tissue. Samples of the healthy individuals have a uniform distribution of beta-distribution forms. We found that this distribution has the maximal information entropy. At 20 cm and 10 cm away from cancer\, the transition forms redistribute into unoriented and highly oriented forms. Closer to cancer the number of unoriented forms decreases rapidly leaving only highly oriented forms present in the samples of the cancer tissue\, whose distribution has minimal information entropy. The polarization of the distribution was followed by a significant increase in the number of quasi-symmetrical forms in samples 20 cm away from cancer which decreases closer to cancer.\nThis work shows that the evolution of the distribution of the beta-distribution forms – an abstract construction of the mind – follows the familiar laws of statistical mechanics. Additionally\, the polarization of the beta-distribution forms together with the described change in the number of quasi-symmetrical forms\, clearly visible in the parametric space of the beta-distribution and very difficult to notice in the observable space\, can be a useful indicator of the early stages in the development of colorectal cancer.
URL:/event/the-morphological-analysis-of-the-collagen-straightness-in-the-colon-mucosa-away-from-the-cancer/
LOCATION:Aula Seminari\, Via Enrico Fermi\, 40\, Frascati\, Roma\, 00044\, Italia
CATEGORIES:Seminari teorici
END:VEVENT
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